Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約10-14 週間 | ¥ 145,000 |
50 mg | 約10-14 週間 | ¥ 189,000 |
100 mg | 約10-14 週間 | ¥ 323,500 |
説明 | S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity. |
ターゲット&IC50 | BCL-XL:186 nM (kd)(ki), BCL-XL:520 nM (ki), BCL2:1.3 nM (ki), BCL2:3.9 nM (kd) |
In vitro | S55746 selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner.S55746 (0-1 μM) potently and selectively induces cell death. |
In vivo | S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active inhibitor of BCL-2 . In RS4, S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth;11 and Toledo models time- and dose-dependently. |
別名 | BLC201 (hydrochloride) |
分子量 | 747.28 |
分子式 | C43H43ClN4O6 |
CAS No. | 1448525-91-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
S55746 hydrochloride 1448525-91-4 Apoptosis BCL S-55746 Hydrochloride BLC 201 BLC201 S55746 Hydrochloride BLC-201 S 55746 Hydrochloride S-55746 hydrochloride BLC201 (hydrochloride) Inhibitor inhibitor inhibit