Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SJ6986 is a potent, selective and orally active GSPT1/2 degrader. SJ6986 degrades GSPT1 with a DC 50 of 2.1 nM (D max 99%) [1].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 18,000 | |||
25 mg | 在庫あり | ¥ 33,000 | |||
50 mg | 在庫あり | ¥ 59,000 | |||
100 mg | 在庫あり | ¥ 91,500 | |||
500 mg | 在庫あり | ¥ 217,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,500 |
説明 | SJ6986 is a potent, selective and orally active GSPT1/2 degrader. SJ6986 degrades GSPT1 with a DC 50 of 2.1 nM (D max 99%) [1]. |
In vitro | SJ6986 demonstrates potency with EC50 values at 1.5 nM, 0.4 nM, 726 nM, 336 nM, and 3583 nM in the MV4-11, MHH-CALL-4, MB002, MB004, and HD-MB03 cell lines respectively [1]. In MV4-11 cells, under conditions of a 0-100 μM concentration range and a 3-day incubation, an EC50 of 1.5 nM was observed, indicating significant inhibition of cell proliferation [1]. Additionally, Western Blot analysis in the same cell line, with a concentration range of 0-10 μM over 4 and 24 hours, revealed a dose- and time-dependent reduction in GSPT1 protein levels, further confirming the compound's efficacy [1]. |
In vivo | SJ6986 shows t 1/2 of 3.44 h by intravenous injection of 3 mg/kg and t max of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice [1]. |
分子量 | 497.4 |
分子式 | C20H14F3N3O7S |
CAS No. | 2765625-93-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (110.57 mM)
You can also refer to dose conversion for different animals. 詳細
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SJ6986 2765625-93-0 Others SJ 6986 SJ-6986 Inhibitor inhibitor inhibit