store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secretion, causes gallbladder contractions and relaxes the sphincter of Oddi, thereby facilitating bile drainage into the duodenum. Sincalide ammonium promotes bile secretion, contraction of the gallbladder and relaxation of the sphincter of Oddi, thereby facilitating the drainage of bile into the duodenum.Sincalide ammonium can be injected to promote gallbladder contraction, and is commonly used as an adjunct in the diagnosis of gallbladder and pancreatic diseases and in cholecystography.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 20,500 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 91,500 | |||
25 mg | 在庫あり | ¥ 150,000 | |||
50 mg | 在庫あり | ¥ 209,500 | |||
100 mg | 在庫あり | ¥ 282,500 | |||
500 mg | 在庫あり | ¥ 564,500 |
説明 | Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secretion, causes gallbladder contractions and relaxes the sphincter of Oddi, thereby facilitating bile drainage into the duodenum. Sincalide ammonium promotes bile secretion, contraction of the gallbladder and relaxation of the sphincter of Oddi, thereby facilitating the drainage of bile into the duodenum.Sincalide ammonium can be injected to promote gallbladder contraction, and is commonly used as an adjunct in the diagnosis of gallbladder and pancreatic diseases and in cholecystography. |
In vitro | Sincalide ammonium, also known as cholecystokinin octapeptide ammonium or CCK-8 ammonium, functions as a novel cardiovascular hormone with a significant inhibitory effect on myocardial fibrosis in noninfarcted areas. It also exhibits a positive role in combating inflammation, apoptosis, and collagen deposition. In the context of H9c2 cardiomyoblasts, CCK‐8 (ammonium) protects cells from Ang II-induced apoptosis, partly through the activation of the CCK1 receptor and the phosphatidylinositol‐3 kinase/protein kinase B (PI3K/Akt) signaling pathway[4]. |
In vivo | In a rat model of myocardial infarction (MI), Sincalide ammonium, also known as cholecystokinin octapeptide ammonium or CCK-8 ammonium, alleviates fibrosis in the noninfarcted regions. Furthermore, it delays left ventricular remodeling and the progression of heart failure in the MI rat model[3]. |
別名 | SQ19844 ammonium, CCK-8 ammonium, Cholecystokinin octapeptide ammonium |
分子量 | 1160.3 |
分子式 | C49H65N11O16S3 |
CAS No. | 70706-98-8 |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 30 mg/mL, Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Sincalide ammonium 70706-98-8 GPCR/G Protein cholecystokinin SQ19844 ammonium CCK-8 ammonium Cholecystokinin octapeptide ammonium Inhibitor inhibitor inhibit