Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 41,000 | |||
5 mg | 在庫あり | ¥ 86,000 | |||
10 mg | 在庫あり | ¥ 137,000 | |||
25 mg | 在庫あり | ¥ 221,500 | |||
50 mg | 在庫あり | ¥ 296,000 | |||
100 mg | 在庫あり | ¥ 404,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 94,500 |
説明 | SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease. |
In vitro | SynuClean-D prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells. SynuClean-D significantly reduces the aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio. SynuClean-D can bind to cavities in mature α-synuclein fibrils[1]. |
In vivo | SynuClean-D-treated worms show decreased α-synuclein aggregation in muscle and a concomitant motility recovery. SynuClean-D is able to rescue dopaminergic neurons from α-synuclein-induced degeneration[1]. In two parkinson’s disease (PD) Caenorhabditis elegans models, SynuClean-D expresses α-synuclein either in muscle or in dopaminergic neurons and significantly reduces the toxicity exerted by α-synuclein[1]. |
別名 | SC-D |
分子量 | 354.2 |
分子式 | C13H5F3N4O5 |
CAS No. | 685121-45-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 77 mg/mL (217.39 mM)
You can also refer to dose conversion for different animals. 詳細
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SynuClean-D 685121-45-3 Others inhibit Inhibitor SynuClean D SC-D SynuCleanD inhibitor