Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors.
説明 | TBOPP is a selective DOCK1 inhibitor (IC50 : 8.4 μM), with anti-tumor activity for broader types of tumors. |
ターゲット&IC50 | DOCK1:8.4 μM , DOCK1 DHR-2 domain:7.1 μM (kd) |
In vitro | TBOPP as a selective inhibitor of DOCK1. TBOPP dampened DOCK1-mediated invasion, macropinocytosis, and survival under the condition of glutamine deprivation without impairing the biological functions of the closely related DOCK2 and DOCK5 proteins. |
In vivo | TBOPP treatment suppressed cancer metastasis and growth in vivo in mice. |
分子量 | 490.49 |
分子式 | C24H21F3N2O4S |
CAS No. | 1996629-79-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (244.65 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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TBOPP 1996629-79-8 Others Inhibitor inhibit inhibitor