Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene expression, and reduces dna binding activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 28,000 | |||
25 mg | 在庫あり | ¥ 57,000 | |||
50 mg | 在庫あり | ¥ 84,500 | |||
100 mg | 在庫あり | ¥ 125,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,000 |
説明 | TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene expression, and reduces dna binding activity. |
ターゲット&IC50 | HIF2α:81 nM(kd) |
In vitro | TC-S 7009 (50 μM) treatment almost fully inhibits hypoxia-induced NFATc2 nuclear translocation. TC-S 7009 (0-100 µM; 72 hours; HPF cells) treatment displays greater inhibition of cell proliferation in hypoxic conditions than that in normoxic conditions [2]. |
分子量 | 308.65 |
分子式 | C12H6ClFN4O3 |
CAS No. | 1422955-31-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (145.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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TC-S 7009 1422955-31-4 Angiogenesis Chromatin/Epigenetic HIF TC-S-7009 TC-S7009 TCS 7009 TC S 7009 Inhibitor inhibitor inhibit