store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-cancer activity and anti-HIV activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 18,000 | |||
5 mg | 在庫あり | ¥ 68,000 | |||
10 mg | 在庫あり | ¥ 108,500 | |||
25 mg | 在庫あり | ¥ 178,500 | |||
50 mg | 在庫あり | ¥ 250,500 |
説明 | TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-cancer activity and anti-HIV activity. |
ターゲット&IC50 | CXCR4:19.3 nM, CXCR7:350 nM (EC50) |
In vitro | TC14012 (1 mM) inhibits more than 95% the infection of the CXCR4-expressing cells by the HXB2 (X4) or 89.6 (dual-tropic) strain. TC14012 (1 mM) does not inhibit all the infection of the CCR5-expressing cells by the SF162 (R5) or 89.6 (dualtropic) strain. TC14012 leads to erk 1/2 phosphorylation in U373 cells, which express endogenous CXCR7 but not CXCR4. CXCR7 and the CXCR7-Cter4 chimera are able to recruit arrestin upon stimulation with TC14012 whereas CXCR4 and CXCR4-Cter7 remain silent. |
別名 | TC14012 acetate(368874-34-4 free base) |
分子量 | 2126.47 |
分子式 | C92H144N34O21S2 |
CAS No. | TP2112L |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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TC14012 acetate TP2112L Autophagy GPCR/G Protein Immunology/Inflammation Arrestin CXCR TC-14012 acetate TC 14012 Acetate TC14012 Acetate TC-14012 Acetate TC14012 acetate(368874-34-4 free base) Inhibitor inhibitor inhibit