Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation.
説明 | TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation. |
ターゲット&IC50 | PrPC:3 nM (in ScN2a and F3 cells) |
In vitro | In Schwannoma cells, administration of 0-500 μM TCS PrP Inhibitor 13 reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrPC and increases expression of cleaved caspase-3 significantly. TCS PrP Inhibitor 13 also significantly reduces the number of proliferating, Ki67-positive cells and total cell number in Schwannoma cells[2]. |
別名 | 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One |
分子量 | 281.27 |
分子式 | C15H11N3O3 |
CAS No. | 34320-83-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 88 mg/mL (312.87 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TCS PrP Inhibitor 13 34320-83-7 Others Inhibitor inhibit cellular 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One ScN2a agent Apoptosis antiprion protease-resistant TCS PrP Inhibitor13 prion TCS PrP Inhibitor-13 inhibitor