Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).
説明 | TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM). |
ターゲット&IC50 | FFA1/GPR40:(EC50)32 nM |
In vitro | At equivalent glucose concentrations, TUG-424's roughly double enhancement of secretion in the context of 12 mM glucose parallels the effect triggered by palmitate. Increasing TUG-424 doses (100 nM to 10 µM) significantly boost glucose-stimulated insulin secretion, beginning notably at 100 nM and peaking at 3 µM. Additionally, TUG-424 slightly yet significantly diminishes basal insulin secretion at 2.8 mM glucose [1]. |
別名 | TUG424 |
分子量 | 264.32 |
分子式 | C18H16O2 |
CAS No. | 1082058-99-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (189.16 mM)
You can also refer to dose conversion for different animals. 詳細
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TUG-424 1082058-99-8 Others TUG 424 TUG424 Inhibitor inhibitor inhibit