Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 34,000 | |||
5 mg | 在庫あり | ¥ 77,500 | |||
10 mg | 在庫あり | ¥ 114,000 | |||
25 mg | 在庫あり | ¥ 182,000 | |||
50 mg | 在庫あり | ¥ 259,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 97,000 |
説明 | Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations. |
In vitro | Tepotinib hydrochloride(1 : x) potently inhibits ABCB1 and ABCG2 efflux transporters, which was confirmed by molecular docking. In addition, Tepotinib hydrochloride(1 : x) inhibited several recombinant cytochrome P450 (CYP) isoforms with varying potency. Tepotinib hydrochloride(1 : x) synergistically reversed daunorubicin and mitoxantrone resistance in cells with ABCB1 and ABCG2 overexpression, respectively[2]. |
分子量 | 529.04 |
分子式 | C29H29ClN6O2 |
CAS No. | 1103508-80-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (94.51 mM)
You can also refer to dose conversion for different animals. 詳細
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Tepotinib hydrochloride(1 : x) 1103508-80-0 Membrane transporter/Ion channel Neuroscience Tyrosine Kinase/Adaptors c-Met/HGFR P-gp ABC Inhibitor inhibitor inhibit