Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 20,500 | |||
5 mg | 在庫あり | ¥ 41,000 | |||
10 mg | 在庫あり | ¥ 58,500 | |||
25 mg | 在庫あり | ¥ 105,500 | |||
50 mg | 在庫あり | ¥ 155,500 | |||
100 mg | 在庫あり | ¥ 221,000 |
説明 | Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells. |
別名 | ARC111, ARC 111, ARC-111, Topoval |
分子量 | 421.45 |
分子式 | C23H23N3O5 |
CAS No. | 500214-53-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
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Topovale 500214-53-9 DNA Damage/DNA Repair Topoisomerase ARC111 ARC 111 ARC-111 Topoval Inhibitor inhibitor inhibit