Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UC-112 is a novel potent IAP inhibitor and potently inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM).
説明 | UC-112 is a novel potent IAP inhibitor and potently inhibits cell growth in two human melanoma and two human prostate cancer cell lines (IC50=0.7-3.4 uM). |
In vitro | UC-112 also effectively inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 μM. Coincubation of UC-112 with a known proteasome inhibitor Z-Leu-Leu-Leu-CHO rescued survivin inhibition, consistent with the anticipated mechanism of action for UC-112[1]. |
In vivo | UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo [1]. |
分子量 | 348.44 |
分子式 | C22H24N2O2 |
CAS No. | 383392-66-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30.6 mg/mL (87.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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UC-112 383392-66-3 Others UC 112 UC112 Inhibitor inhibitor inhibit