Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
2 mg | 約 5 days | ¥ 41,000 |
25 mg | 約8-10 週間 | ¥ 262,000 |
50 mg | 約8-10 週間 | ¥ 342,000 |
100 mg | 約8-10 週間 | ¥ 457,000 |
説明 | Vaborbactam (RPX7009) is a β-lactamase inhibitor that is often used in conjunction with meropenem to study pneumonia and CRE infections. |
In vitro | The β-lactamase inhibitor vaborbactam can also form an acyl-enzyme complex with Pseudomonas aeruginosa PBP3. We found that vaborbactam inhibits PBP3 (IC50 of 262 μM), and its binding to PBP3 increases the protein thermal stability by about 2°C[1]. |
In vivo | In a neutropenic mouse thigh infection model, the administration of 100 mg/kg meropenem alone and in combination with various doses of vaborbactam against Klebsiella pneumoniae was evaluated. The results showed that intraperitoneal injection of 300 mg/kg meropenem combined with 50 mg/kg vaborbactam resulted in the greatest reduction in bacterial counts compared to the untreated control group[2]. |
別名 | RPX7009 |
分子量 | 297.14 |
分子式 | C12H16BNO5S |
CAS No. | 1360457-46-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 2 mg/mL (6.73 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Vaborbactam 1360457-46-0 Microbiology/Virology Antibacterial RPX-7009 RPX 7009 RPX7009 Inhibitor inhibitor inhibit