store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine's action in platelets is mediated by PDE III isoenzymes and can be used in studies of acute renal failure and chronic airflow obstruction.
説明 | Zardaverine (BY 290) is an orally available, selective and potent PDE3/4 inhibitor with bronchodilator activity and anti-hepatocarcinogenic activity.Zardaverine's action in platelets is mediated by PDE III isoenzymes and can be used in studies of acute renal failure and chronic airflow obstruction. |
In vitro | Zardaverine selectively inhibits the growth of human hepatocellular carcinoma (HCC) cells in vitro when administered at concentrations ranging from 0 to 30 µM for 72 hours[3].Selective antitumor activity of Zardaverine is observed, closely related to the regulation of cell cycle-associated proteins, but independent of PDE3/4 inhibition[3].At a concentration of 0.1 µM for 24 hours, Zardaverine selectively induces G0/G1-phase arrest and dysregulates cell cycle-associated proteins in HCC cells[3].Zardaverine induces apoptosis in a time- and concentration-dependent manner in Bel-7402 and SMMC-7721 cells. The concentrations used include 0.01, 0.03, 0.1, 0.3, and 1 µM over 48 hours, as well as 0.3 and 1 µM over 24, 36, 48, 60, and 72 hours[3]. |
別名 | BY 290, B 84290 |
分子量 | 268.22 |
分子式 | C12H10F2N2O3 |
CAS No. | 101975-10-4 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (74.57 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Zardaverine 101975-10-4 Metabolism PDE BY 290 B 84290 Inhibitor inhibitor inhibit