Powder: -20°C for 3 years | In solvent: -80°C for 1 year
α-Hydroxyglutaric Acid Lithium, converted from glutamate in microorganisms and animals, is an inhibitor of α-ketoglutarate-dependent dioxygenase and 5-methylcytosine hydroxylase, and has an inhibitory effect on ATP synthase and mTOR signaling.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 18,500 | |||
10 mg | 在庫あり | ¥ 29,500 | |||
25 mg | 在庫あり | ¥ 61,500 | |||
50 mg | 在庫あり | ¥ 91,500 | |||
100 mg | 在庫あり | ¥ 134,000 | |||
500 mg | 在庫あり | ¥ 282,500 |
説明 | α-Hydroxyglutaric Acid Lithium, converted from glutamate in microorganisms and animals, is an inhibitor of α-ketoglutarate-dependent dioxygenase and 5-methylcytosine hydroxylase, and has an inhibitory effect on ATP synthase and mTOR signaling. |
In vitro | α-Hydroxyglutaric Acid Lithium inhibits the activity of multiple histone demethylases. In the active site of histone demethylases, α-Hydroxyglutaric Acid Lithium occupies the same space as α-KG, leading to inhibition of their activity. Additionally, α-Hydroxyglutaric Acid Lithium inhibits the activity of TET 5-methylcytosine hydroxylases[1].Treatment of U-87MG cells with α-Hydroxyglutaric Acid Lithium at concentrations ranging from 10 to 50 mM results in increased levels of HIF-1α and decreased levels of endostatin[1]. |
別名 | α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base) |
分子量 | 159.98 |
分子式 | C5H6Li2O5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1mg/ml, Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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α-Hydroxyglutaric Acid Lithium Metabolism Others PI3K/Akt/mTOR signaling mTOR Endogenous Metabolite Decarboxylase αHydroxyglutaricAcidLithium(2889318Freebase) α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base) Inhibitor inhibitor inhibit