Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 33,000 |
5 mg | 約 35 days | ¥ 145,500 |
10 mg | 約 35 days | ¥ 257,000 |
説明 | AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1]. |
ターゲット&IC50 | EP4 (human):4.3 nM |
In vitro | AMX12006, at concentrations ranging from 0 to 100 µM, exhibits cytotoxic effects with IC50 values of 46.73 µM for MCF-7, 79.47 µM for 4T1, over 100 µM for HCA-7, 41.39 µM for CT-26 WT, and over 100 µM for LLC cells [1]. |
In vivo | AMX12006, administered orally at doses of 75 and 150 mg/kg once daily for 11 days, demonstrated dose-dependent antitumor activity [1]. |
分子量 | 481.47 |
分子式 | C26H22F3N3O3 |
CAS No. | 2639775-01-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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AMX12006 2639775-01-0 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor Inhibitor inhibitor inhibit