store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anti-inflammatory agent 51 is an amide/sulfonamide derivative with anti-inflammatory and potentially anti-tumor activity and inhibition of NF-κB activation, which can be used to study acute lung injury and ulcerative colitis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,000 | |||
2 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 24,500 | |||
25 mg | 在庫あり | ¥ 40,500 | |||
50 mg | 在庫あり | ¥ 60,500 | |||
100 mg | 在庫あり | ¥ 89,500 |
説明 | Anti-inflammatory agent 51 is an amide/sulfonamide derivative with anti-inflammatory and potentially anti-tumor activity and inhibition of NF-κB activation, which can be used to study acute lung injury and ulcerative colitis. |
ターゲット&IC50 | IL-6:0.61 μM (J774A.1 cells), TNF-α:4.34 μM (J774A.1 cells) |
In vitro | Anti-inflammatory agent 51 (compound 11d) effectively reduces the release of IL-6 (IC50 value of 0.61 μM) and TNF-α (IC50 of 4.34 μM), and decreases the mRNA levels of cytokines in J774A.1 cells. Anti-inflammatory agent 51 restores IκBα and inhibits the translocation of phosphorylated p65 to the nucleus [1]. |
In vivo | Anti-inflammatory agent 51 (compound 11d) improves lipopolysaccharide (LPS)-induced acute lung injury (ALI) and alleviates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice [1]. |
分子量 | 498.51 |
分子式 | C22H22N6O6S |
CAS No. | 2911610-03-0 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (100.30 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Anti-inflammatory agent 51 2911610-03-0 NF-Κb NF-κB Antiinflammatoryagent51 Inhibitor inhibitor inhibit