Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ASM-IN-1 is a potent, orally active inhibitor of acid sphingomyelinase (ASM) with an IC50 of 1.5 µM, demonstrating antiatherosclerotic and anti-inflammatory activity. It effectively reduces lipid plaques in the aortic arch and aorta, along with decreasing plasma ceramide concentrations and oxidized LDL (Ox-LDL) levels [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
説明 | ASM-IN-1 is a potent, orally active inhibitor of acid sphingomyelinase (ASM) with an IC50 of 1.5 µM, demonstrating antiatherosclerotic and anti-inflammatory activity. It effectively reduces lipid plaques in the aortic arch and aorta, along with decreasing plasma ceramide concentrations and oxidized LDL (Ox-LDL) levels [1]. |
In vitro | ASM-IN-1 (compound 4i) does not affect cell growth in HUVEC [1]. ASM-IN-1 at concentrations of 0, 1, and 5 µM reduces the expression of IL-6 and TNF-α in HUVEC in a dose-dependent manner upon LPS stimulation [1]. Additionally, ASM-IN-1 at 5 µM decreases the expression of MCP-1 mRNA and normalizes IL-6 mRNA levels in the presence of Ox-LDL [1]. |
In vivo | ASM-IN-1, administered via intravenous injection at 1 mg/kg and orally at 10 mg/kg, demonstrated favorable pharmacokinetic properties in ICR mice with an oral bioavailability of 35.42% [1]. When given intraperitoneally at doses of 6, 12, and 40 mg/kg twice daily for a duration of 8 weeks, ASM-IN-1 exhibited anti-atherosclerotic activity by inhibiting ASM activity in mice [1]. |
分子量 | 390.19 |
分子式 | C16H12BrN3O4 |
CAS No. | 2913151-46-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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ASM-IN-1 2913151-46-7 Metabolism Phospholipase Inhibitor inhibitor inhibit