Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.
説明 | DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM. |
In vitro | DPTIP (30 μM) decreases exosome release by 50% in astrocytes. DPTIP(0.03-30 μM) dose-dependently blocks EV secretion[1]. |
In vivo | In mice, DPTIP potently (10 mg/kg; i.p.) inhibits IL-1β-induced astrocyte-derived EV release. Brain concentrations of DPTIP are above its IC50 for neutral sphingomyelinase 2 inhibition for at least 4 h after the administration of DPTIP[2]. |
分子量 | 378.44 |
分子式 | C21H18N2O3S |
CAS No. | 351353-48-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 245 mg/mL (647.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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DPTIP 351353-48-5 Metabolism Phospholipase extracellular Inhibitor exosome vesicles inhibit N-SMase inhibitor