Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-4142 is an orally active, potent and selective HER2 inhibitor that inhibits cancer cell proliferation, suppresses her2-dependent cell lines and inhibits downstream signalling.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 52,000 |
5 mg | 在庫あり | ¥ 129,000 |
10 mg | 在庫あり | ¥ 203,000 |
25 mg | 在庫あり | ¥ 333,000 |
50 mg | 在庫あり | ¥ 454,500 |
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 148,000 |
説明 | BI-4142 is an orally active, potent and selective HER2 inhibitor that inhibits cancer cell proliferation, suppresses her2-dependent cell lines and inhibits downstream signalling. |
ターゲット&IC50 | Ba/F3 EGFRWT:2400 nM, Ba/F3 HER2YVMA:18 nM, HER2:5 nM, HEK HER2YVMA:10 nM, HEK EGFRWT:270 nM |
In vitro |
BI-4142 inhibits HER2-dependent cell lines and downstream signaling, with IC50 values of 10 nM, 18 nM, 270 nM, and 2400 nM against HEK HER2YVMA, Ba/F3 HER2YVMA, HEK EGFRWT, and Ba/F3 EGFRWT, respectively[1].BI-4142 (1 nM-5 μM, 72 h or 96 h) exhibits antiproliferative activity against tumor cells[1]. In the CaCo-2 assay, BI-4142 displays good permeability and no PgP-mediated efflux liability[1]. |
In vivo | BI-4142 administered at doses ranging from 0 to 100 mg/kg, orally twice daily for 40 days, significantly inhibits tumor growth and suppresses oncogenic signaling[1]. |
分子量 | 521.57 |
分子式 | C28H27N9O2 |
CAS No. | 2682003-36-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (153.38 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BI-4142 2682003-36-5 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors HER Inhibitor inhibitor inhibit