Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 119,000 |
5 mg | 在庫あり | ¥ 268,500 |
25 mg | 在庫あり | ¥ 441,000 |
50 mg | 在庫あり | ¥ 546,500 |
100 mg | 約6-8週間 | ¥ 711,500 |
説明 | Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be used to study prostate cancer. |
ターゲット&IC50 | P-gp:0.75uM(EC50), Iodoaryl azido-prazosin:0.55 μM(EC50) |
In vitro | Biricodar exhibits activity against both P-glycoprotein (Pgp) and MRP-1, enhancing drug uptake and retention while reversing drug resistance mediated by wild-type BCRP (BCRPR482). In Pgp-expressing 8226/Dox6 cells, biricodar increases the uptake of mitoxantrone and daunorubicin by 55% and 100%, respectively. It enhances their retention by 100% and 60%, respectively, and boosts their cytotoxicity by 3.1- and 6.9-fold, respectively. Furthermore, biricodar has similar effects on HL60/Adr cells (MRP-1) and 8226/MR20 cells (BCRP(R482)), but it has little impact on MCF7 AdVP3000 cells (BCRP(R482T))[1]. VX-710, a non-macrocyclic pipecolinate derivative binding to the FK506 receptor protein, has been shown to restore sensitivity in various multidrug-resistant cells, including myeloma, melanoma, carcinoma, and leukemia[2]. Additionally, biricodar effectively inhibits the photoaffinity labeling of P-glycoprotein by [3H]azidopine or [125I]iodoaryl azido-prazosin, with EC50 values of 0.75 and 0.55 μM[3]. |
別名 | VX 710, VX 710-3 |
分子量 | 987.95 |
分子式 | C46H57N3O21 |
CAS No. | 174254-13-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Biricodar dicitrate 174254-13-8 Neuroscience NF-Κb NF-κB AChR VX 710 Biricodar VX710 VX-710 VX 710-3 Biricodar Dicitrate Inhibitor inhibitor inhibit