Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1). This compound facilitates the degradation of CARM1 via the VHL-proteasome pathway. By degrading CARM1, PROTAC CARM1 degrader-1 effectively reduces the methylation of its substrates, including poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, subsequently inhibiting breast cancer cell migration [1].
説明 | PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1). This compound facilitates the degradation of CARM1 via the VHL-proteasome pathway. By degrading CARM1, PROTAC CARM1 degrader-1 effectively reduces the methylation of its substrates, including poly(A)-binding protein PABP1 and BGR1-associated factor BAF155, subsequently inhibiting breast cancer cell migration [1]. |
分子量 | 1279.68 |
分子式 | C71H98N12O8S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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CARM1 degrader-1 Chromatin/Epigenetic Histone Methyltransferase Inhibitor inhibitor inhibit