Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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50 mg | 在庫あり | ¥ 8,500 | |||
100 mg | 在庫あり | ¥ 11,500 | |||
200 mg | 在庫あり | ¥ 17,500 | |||
500 mg | 在庫あり | ¥ 27,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. |
ターゲット&IC50 | Histamine N-methyl transferase:18.6 nM(Ki) |
In vivo | In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs[3]. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation[1]. |
キナーゼ試験 | Whole-cell competitive binding assays: Whole-cell competitive binding assays are performed in LNCaP/AR(codon-switch) (LNCaP/AR(cs)) (harbors a mixture of exogenous wild-type AR and endogenous mutant AR (T877A)) and cells propagated in Iscove's or RPMI media supplemented with 10% fetal bovine serum, or during the assay with 10% charcoal-stripped, dextran-treated fetal bovine serum (CSS). Cells are pre-incubated with 18F-FDHT, increasing concentrations (1pM to 1 μM) of cold Bicalutamide are added, and the assay is performed to measure specific uptake of 18F-FDHT (4). IC50 values are determined using a one site binding model with least squares curve fitting and R2 > 0.99. |
別名 | Amodiaquine hydrochloride, Amodiaquin dihydrochloride dihydrate |
分子量 | 464.82 |
分子式 | C20H28Cl3N3O3 |
CAS No. | 6398-98-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 85 mg/mL (182.9 mM)
H2O: 27 mg/mL (58.1 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Amodiaquine dihydrochloride dihydrate 6398-98-7 Chromatin/Epigenetic GPCR/G Protein Immunology/Inflammation Microbiology/Virology Neuroscience Histone Methyltransferase Parasite Histamine Receptor antimalarial anti-inflammatory CXCL2 CCL2 N-methyltransferase neuroprotective Amodiaquine hydrochloride Amodiaquin dihydrochloride Dihydrate Inhibitor Amodiaquine Amodiaquine Hydrochloride Amodiaquine dihydrochloride Dihydrate IL-1β Nurr1 Amodiaquin dihydrochloride dihydrate inhibit Amodiaquin inhibitor