Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 41,000 | |||
5 mg | 在庫あり | ¥ 102,500 | |||
10 mg | 在庫あり | ¥ 150,500 | |||
25 mg | 在庫あり | ¥ 226,500 | |||
50 mg | 在庫あり | ¥ 321,500 | |||
100 mg | 在庫あり | ¥ 431,500 | |||
500 mg | 在庫あり | ¥ 867,500 |
説明 | CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4 and 5.3 nM, respectively. |
ターゲット&IC50 | sEH (mouse):0.4 nM |
In vivo | Oral administration of 13 1-aryl-3-(1-acylpiperidin-4-yl)urea (CAY10640) inhibitors in mice revealed substantial improvements in pharmacokinetic parameters over previously reported 1-adamantylurea based inhibitors. This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model.[1] |
別名 | sEH inhibitor-1 |
分子量 | 371.35 |
分子式 | C17H20F3N3O3 |
CAS No. | 1208549-68-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 4.5 mg/mL (12.2 mM)
Ethanol: 2 mg/mL
DMSO: 4.5 mg/mL (12.2 mM)
You can also refer to dose conversion for different animals. 詳細
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CAY10640 1208549-68-1 Metabolism Epoxide Hydrolase CAY 10640 sEH inhibitor-1 CAY-10640 Inhibitor inhibitor inhibit