Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CP 465022 hydrochloride is a potent, and selective noncompetitive antagonist of AMPA receptor with anticonvulsant activity. CP 465022 hydrochloride inhibits Kainate-induced response with an IC50 of 25 nM in rat cortical neurons.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 18,500 | |||
10 mg | 在庫あり | ¥ 29,500 | |||
25 mg | 在庫あり | ¥ 64,000 | |||
50 mg | 在庫あり | ¥ 112,000 | |||
100 mg | 在庫あり | ¥ 160,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
説明 | CP 465022 hydrochloride is a potent, and selective noncompetitive antagonist of AMPA receptor with anticonvulsant activity. CP 465022 hydrochloride inhibits Kainate-induced response with an IC50 of 25 nM in rat cortical neurons. |
ターゲット&IC50 | Kainate-induced response:25 nM (rat cortical neurons) |
In vitro | CP 465022 hydrochloride 1 µM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%.CP-465,022 at 10 µM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons. CP 465022 hydrochloride (0.0001 μM-10 μM) inhibits kainate-induced response in relatively slow manner and dependents on compound concentration, exhibiting a calculated IC50 of 25 nM and essentially complete inhibition at 3.2 µM. CP 465022 hydrochloride 1 µM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons. CP 465022 hydrochloride (100 nM -10 µM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465,022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 µM CP-465,022 nearly complete inhibits this time frame (99.3%)[1]. |
分子量 | 462.95 |
分子式 | C26H24ClFN4O |
CAS No. | 199655-36-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.63 mg/mL (10 mM)
You can also refer to dose conversion for different animals. 詳細
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CP 465022 199655-36-2 Membrane transporter/Ion channel Neuroscience iGluR CP 465022 hydrochloride CP465022 CP-465022 Inhibitor inhibitor inhibit