Powder: -20°C for 3 years | In solvent: -80°C for 1 year
dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquitin ligase. Ligand that recruits the cereblon E3 ubiquitin ligase. dBRD9 can inhibit the degradation of BRD9 in MOLM-13 cells, and the IC50 is 104 nM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 30,000 | |||
5 mg | 在庫あり | ¥ 75,500 | |||
10 mg | 在庫あり | ¥ 121,500 | |||
25 mg | 在庫あり | ¥ 211,500 | |||
50 mg | 在庫あり | ¥ 319,000 | |||
100 mg | 在庫あり | ¥ 443,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 105,000 |
説明 | dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquitin ligase. Ligand that recruits the cereblon E3 ubiquitin ligase. dBRD9 can inhibit the degradation of BRD9 in MOLM-13 cells, and the IC50 is 104 nM. |
ターゲット&IC50 | BRD9 (MOLM-13 cells):104 nM |
In vitro | dBRD9 has prompt rapid BRD9 degradation over a broad range of concentrations. The degraded BRD9 showed significantly enhanced efficacy(10-to-100-fold). These findings reveal the tractability of non-BET bromodomain-containing proteins to chemical degradation and highlight lead compound dBRD9 as a tool for the study of BRD9[1]. |
In vivo | The final concentration of dBRD9 of 0.3 nM was mixed in silk fibroin hydrogel and injected into mice. It was found that BRD9 degradant alleviated ZOL-related ONJ. The ONJ-dBRD9 group is filled with well-organized newly formed trabecular bone, with 80% reduced incidence rate of osteonecrosis and periosteal reaction compared with the ONJ-control group[1]. |
別名 | dBRD-9, dBRD 9 |
分子量 | 783.83 |
分子式 | C40H45N7O10 |
CAS No. | 2170679-45-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (114.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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dBRD9 2170679-45-3 PROTAC PROTACs dBRD-9 dBRD 9 Inhibitor inhibitor inhibit