Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ensaculin (Anseculin), a novel benzopyrone partially substituted with piperazine, showed memory-enhancing effects in passive and conditioned avoidance paradigms in normal and artificially amnesic rodents. It showed neuroprotective activity in a model of NMDA toxicity and neurotrophic effects in primary cultured rat brain cells.Ensaculin can be used for the treatment of dementia.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 29,500 | |||
5 mg | 在庫あり | ¥ 73,500 | |||
10 mg | 在庫あり | ¥ 108,000 | |||
25 mg | 在庫あり | ¥ 177,500 | |||
50 mg | 在庫あり | ¥ 248,000 | |||
100 mg | 在庫あり | ¥ 335,000 | |||
500 mg | 在庫あり | ¥ 670,500 |
説明 | Ensaculin (Anseculin), a novel benzopyrone partially substituted with piperazine, showed memory-enhancing effects in passive and conditioned avoidance paradigms in normal and artificially amnesic rodents. It showed neuroprotective activity in a model of NMDA toxicity and neurotrophic effects in primary cultured rat brain cells.Ensaculin can be used for the treatment of dementia. |
ターゲット&IC50 | D2:16.6 nM, D3:27.7 nM, D4:277 nM, α1A:4.7 nM, α1B:9.3 nM, α:>100 nM, 5-HT1A:8 nM, 5-HT2:>100 nM |
In vivo | Ensaculin (0.1, 1 and 10 mg/kg; i.p.; Wistar rats; 20 min after the onset of glutamate perfusion) significantly antagonized the formation of 2,3-DHBA, to values of 60.5% and 56.7% of control levels, respectively. Ensaculin may be useful in the treatment of neurodegenerative disorders associated with elevated hydroxyl free radicals and excitotoxicity.[1] |
別名 | Anseculin |
分子量 | 452.54 |
分子式 | C26H32N2O5 |
CAS No. | 155773-59-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 42.6 mg/mL (94.03 mM ), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Ensaculin 155773-59-4 Anseculin Inhibitor inhibitor inhibit