Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Erinacine A is an anticancer compound that can be extracted from the monkey head mushroom and is capable of inducing cancer cell death through the production of reactive oxygen species (ROS).Erinacine A may exert its anticancer activity by participating in the modulation of signaling pathways.Erinacine A has anticancer, antitumor, and neuroprotective activities.
説明 | Erinacine A is an anticancer compound that can be extracted from the monkey head mushroom and is capable of inducing cancer cell death through the production of reactive oxygen species (ROS).Erinacine A may exert its anticancer activity by participating in the modulation of signaling pathways.Erinacine A has anticancer, antitumor, and neuroprotective activities. |
In vitro | Erinacine A (1-10 µM; 24 h) treatment of TSGH 9201 cells increased cytotoxicity and the generation of reactive oxygen species (ROS), as well as decreased invasiveness. Treatment of TSGH 9201 cells with erinacine A resulted in the activation of caspases and the expression of TRAIL. Erinacine A induction of apoptosis was accompanied by sustained phosphorylation of FAK/AKT/p70S6K and the PAK1 pathways, as well as the generation of ROS. Furthermore, the induction of apoptosis and anti-invasion properties by erinacine A could involve the differential expression of the 14-3-3 sigma protein (1433S) and microtubule-associated tumor suppressor candidate 2 (MTUS2), with the activation of the FAK/AKT/p70S6K and PAK1 signaling pathways. These results lead us to speculate that erinacine A may generate an apoptotic cascade in TSGH 9201 cells by activating the FAK/AKT/p70S6K/PAK1 pathway and upregulating proteins 1433S and MTUS2, providing a new mechanism underlying the anti-cancer effects of erinacine A in human gastric cancer cells.[1] |
分子量 | 432.55 |
分子式 | C25H36O6 |
CAS No. | 156101-08-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Erinacine A 156101-08-5 Immunology/Inflammation ROS ErinacineA Inhibitor inhibitor inhibit