Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).
説明 | GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays). |
In vitro | GSK2795039 (25 μM; 24 hours) decreases the combinatory effect of FeSO4 and LPS-increased levels of apoptosis. It also reduced the presence of caspase-3-positive PC12 cells[2]. |
In vivo | GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) reduces activity in a murine model of acute pancreatitis. It also decreases the levels of serum amylase triggered by systemic injection of cerulein[1]. |
分子量 | 450.56 |
分子式 | C23H26N6O2S |
CAS No. | 1415925-18-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31 mg/mL(68.8 mM)
You can also refer to dose conversion for different animals. 詳細
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GSK2795039 1415925-18-6 Apoptosis Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species NADPH ROS Inhibitor NADPH Oxidase NOX inhibit GSK-2795039 GSK 2795039 inhibitor