Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FEN1-IN-3 is a human flap endonuclease-1 ( hFEN1 ) inhibitor that stabilizes hFEN1 with an EC 50 of 6.8 μM .
説明 | FEN1-IN-3 is a human flap endonuclease-1 ( hFEN1 ) inhibitor that stabilizes hFEN1 with an EC 50 of 6.8 μM . |
ターゲット&IC50 | FEN1 (human):6.8 μM(EC50) |
In vitro | FEN1 inhibition selectively impairs colon cancer cell proliferation in Cdc4 and Mre11a deficiencies, both common in colorectal cancers. FEN1 is a potential chemosensitizer, critical for repairing Methyl methanesulfonate-induced alkylation damage. Knockdown or inhibition increases Temozolomide sensitivity in glioblastoma and colorectal cancer cells.[1] |
分子量 | 284.27 |
分子式 | C15H12N2O4 |
CAS No. | 2109805-87-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (175.89 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
FEN1-IN-3 2109805-87-8 FEN1 IN 3 FEN1IN3 Inhibitor inhibitor inhibit