Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4). This compound demonstrates nanomolar potency in inhibiting proliferation of various cancer cells and significantly hinders tumor growth in xenograft mouse models [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 418,000 |
50 mg | 約8-10 週間 | ¥ 546,500 |
100 mg | 約8-10 週間 | ¥ 711,500 |
説明 | FGFR-IN-11 (compound I-5) is an orally active, covalent inhibitor of FGFR, exhibiting IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4). This compound demonstrates nanomolar potency in inhibiting proliferation of various cancer cells and significantly hinders tumor growth in xenograft mouse models [1]. |
ターゲット&IC50 | FGFR1:9.9 nM, FGFR2:3.1 nM, FGFR3:16 nM, FGFR4:1.8 nM |
In vitro | FGFR-IN-11, at concentrations ranging from 0.3 nM to 20 μM over a 72-hour period, effectively inhibits the growth of various cancer cell lines [1]. |
In vivo | FGFR-IN-11, administered orally at a dose of 60 mg/kg daily for 21 days, significantly inhibited tumor growth in female nude mouse xenograft models of Huh-7 or NCI-H1581 without affecting the mouse body weight. [1] |
分子量 | 521.01 |
分子式 | C28H29ClN4O4 |
CAS No. | 2658488-68-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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FGFR-IN-11 2658488-68-5 Angiogenesis Tyrosine Kinase/Adaptors FGFR Inhibitor inhibitor inhibit