Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GPX4-IN-4 (Compound 24) serves as a potent inhibitor of GPX4, applicable in cancer research [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 383,500 |
50 mg | 約8-10 週間 | ¥ 500,500 |
100 mg | 約8-10 週間 | ¥ 643,000 |
説明 | GPX4-IN-4 (Compound 24) serves as a potent inhibitor of GPX4, applicable in cancer research [1]. |
In vitro | GPX4-IN-4 (Compound 24) reduces HT1080 cell viability in a dose- and time-dependent fashion at concentrations ranging from 0 to 1000 nM and durations up to 24 hours [1]. Similarly, GPX4-IN-4 demonstrates inhibitory effects on NCI-H1703 cell viability over 72 hours, with EC50 values of 0.117 μM without Fer-1 and 4.74 μM with Fer-1 [1]. |
In vivo | GPX4-IN-4 (Compound 24; 100 and 200 mg/kg; i.p.; once) targets renal GPX4 and induces the expression of PD biomarkers in mice [1]. Despite partial target engagement observed in tumor masses, GPX4-IN-4 (50 mg/kg; i.p.; daily for 20 days) does not affect the growth of WSU-DLCL2 tumors in mice [1]. |
分子量 | 460.93 |
分子式 | C22H21ClN2O5S |
CAS No. | 2920221-53-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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GPX4-IN-4 2920221-53-8 Metabolism Glutathione Peroxidase Inhibitor inhibitor inhibit