Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HBV-IN-4, a derivative of phthalazinone, functions as a potent, orally active inhibitor of HBV DNA replication, exhibiting an IC50 value of 14 nM. It effectively induces the formation of genome-free capsids, demonstrating significant anti-HBV potency[1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約6-8 週間 | ¥ 68,500 |
25 mg | 約6-8 週間 | ¥ 210,500 |
50 mg | 約6-8 週間 | ¥ 273,500 |
100 mg | 約6-8 週間 | ¥ 427,000 |
説明 | HBV-IN-4, a derivative of phthalazinone, functions as a potent, orally active inhibitor of HBV DNA replication, exhibiting an IC50 value of 14 nM. It effectively induces the formation of genome-free capsids, demonstrating significant anti-HBV potency[1]. |
ターゲット&IC50 | HBV DNA replication:14 nM (IC50) |
In vitro | HBV-IN-4 (compound 19f; 0-1 μM; 8 days) effectively inhibits different forms (relaxed circular [rc] and single-stranded [ss] HBV DNA) of the Hepatitis B virus in a dose-dependent fashion in HepG2.2.15 cells. Additionally, this treatment dose-dependently decreases capsid-associated DNAs and promotes the generation of genome-free capsids, notably those exhibiting a phenotype of accelerated migration[1]. |
In vivo | HBV-IN-4 (Compound 19f; 50-150 mg/kg; oral administration; twice a day; for 4 weeks; Balb/c male mice) treatment achieves 2.67 log viral load reduction in AAV-HBV/mouse model[1].HBV-IN-4 (compound 19f) exhibits favorable drug characteristics with low plasma clearance (CL=4.1 mL/min/kg), excellent drug exposure (AUC0-t=49 744 h?ng/L), T1/2 (2.15 hours) and oral bioavailability (F=60.4%) using 20 mg/kg oral administration in mice. HBV-IN-4 also shows good distribution in liver exposure[1]. |
分子量 | 479.89 |
分子式 | C24H19ClFN5O3 |
CAS No. | 2305897-84-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (208.38 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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HBV-IN-4 2305897-84-9 HBV IN 4 HBVIN4 Inhibitor inhibitor inhibit