Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-61432059 is an oral active and selective negative modulator of TARP γ‑8 Selective AMPAR(pIC50: 9.7).
説明 | JNJ-61432059 is an oral active and selective negative modulator of TARP γ‑8 Selective AMPAR(pIC50: 9.7). |
ターゲット&IC50 | AMPAR:(pic50)9.7 |
In vivo | In mouse hippocampus, Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models. |
分子量 | 443.47 |
分子式 | C25H22FN5O2 |
CAS No. | 2035814-50-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 42.5 mg/mL (95.84 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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JNJ-61432059 2035814-50-5 Membrane transporter/Ion channel Neuroscience iGluR JNJ 61432059 Inhibitor Ionotropic glutamate receptors JNJ61432059 inhibit inhibitor