Powder: -20°C for 3 years | In solvent: -80°C for 1 year
hCAI/II-IN-6 is a selective and orally active inhibitor of human carbonic anhydrase (CA). hCAI/II-IN-6 inhibited hCA I, hCA II, hCA VII, and hCA XII with Ki values of 220, 4.9, 6.5, and >50,000 nM. hCAI/II-IN-6 showed anticonvulsant activity in vivo. hCAI/II-IN-6 can be used to study epilepsy. hCAI/II-IN-6 showed anticonvulsant activity in vivo. hCAI/II-IN-6 can be used to study epilepsy.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 25,000 | |||
25 mg | 在庫あり | ¥ 52,000 | |||
50 mg | 在庫あり | ¥ 84,500 | |||
100 mg | 在庫あり | ¥ 136,000 | |||
500 mg | 在庫あり | ¥ 289,500 |
説明 | hCAI/II-IN-6 is a selective and orally active inhibitor of human carbonic anhydrase (CA). hCAI/II-IN-6 inhibited hCA I, hCA II, hCA VII, and hCA XII with Ki values of 220, 4.9, 6.5, and >50,000 nM. hCAI/II-IN-6 showed anticonvulsant activity in vivo. hCAI/II-IN-6 can be used to study epilepsy. hCAI/II-IN-6 showed anticonvulsant activity in vivo. hCAI/II-IN-6 can be used to study epilepsy. |
ターゲット&IC50 | CA XII (human):>50000 nM(Ki ), CA VII (human):6.5 nM(Ki ), CA (human):220 nM(Ki ), CA II (human):4.9 nM(Ki ) |
In vitro | hCAI/II-IN-6 (0-50 μM) displays inhibitory effects on the activities of hCA I, hCA II, hCA VII, and hCA XII, exhibiting Ki values of 220 nM, 4.9 nM, 6.5 nM, and >50000 nM, respectively.[1] |
In vivo |
In vivo, hCAI/II-IN-6 (30-100mg/kg; i.p. once; Swiss albino mice) provided seizure attenuation and good anticonvulsant effect and showed an ED 50 of 13.7mg/kg in anticonvulsant quantification study. [1] In vivo, hCAI/II-IN-6 (30 mg/kg; p.o.; once; Swiss albino mice) has been observed to possess anti-MES (maximal electroshock seizure) activity.[1] |
分子量 | 388.48 |
分子式 | C19H24N4O3S |
CAS No. | 694466-00-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (579.2 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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hCAI/II-IN-6 694466-00-7 Metabolism Carbonic Anhydrase Inhibitor inhibitor inhibit