Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HG106, which is anti-inflammatory and may be used to treat the growth of diseases such as malignant tumours caused by mutations in the RAS gene., which is anti-inflammatory and may be used to treat the growth of diseases such as malignant tumours caused by mutations in the RAS gene.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 13,500 | |||
5 mg | 在庫あり | ¥ 34,000 | |||
10 mg | 在庫あり | ¥ 55,000 | |||
25 mg | 在庫あり | ¥ 104,500 | |||
50 mg | 在庫あり | ¥ 151,000 | |||
100 mg | 在庫あり | ¥ 211,000 | |||
500 mg | 在庫あり | ¥ 420,000 |
説明 | HG106, which is anti-inflammatory and may be used to treat the growth of diseases such as malignant tumours caused by mutations in the RAS gene., which is anti-inflammatory and may be used to treat the growth of diseases such as malignant tumours caused by mutations in the RAS gene. |
In vitro | We identified a potent SLC7A11 inhibitor, HG106, that markedly decreased cystine uptake and intracellular glutathione biosynthesis. Furthermore, HG106 exhibited selective cytotoxicity toward KRAS-mutant cells by increasing oxidative stress- and ER stress-mediated cell apoptosis. [1] |
In vivo | Treatment of KRAS-mutant LUAD with HG106 in several preclinical lung cancer mouse models led to marked tumor suppression and prolonged survival. [1] |
分子量 | 316.74 |
分子式 | C15H13ClN4O2 |
CAS No. | 928712-10-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
Ethanol: Insoluble
DMSO: 18.9 mg/mL (59.7 mM)
You can also refer to dose conversion for different animals. 詳細
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HG106 928712-10-1 Others Acetamide,2chloroN[2(4methoxyphenyl)2Hbenzotriazol5yl] HG-106 HG 106 Inhibitor inhibitor inhibit