Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) release from inflammatory vesicles.
説明 | JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1β and lactate dehydrogenase (LDH) release from inflammatory vesicles. |
In vivo | JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibited the release of caspase-1 (p20) and IL-1β from the non-canonical (NC) inflammasome in the C57BL/6 mouse model, attenuated NC inflammasome activation.[1] |
分子量 | 302.3 |
分子式 | C17H15FO4 |
CAS No. | 937820-89-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (297.7 mM)
You can also refer to dose conversion for different animals. 詳細
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JC2-11 937820-89-8 Apoptosis Immunology/Inflammation Metabolism Proteases/Proteasome ROS Caspase NOD-like Receptor (NLR) AIM2 Dehydrogenase IL Receptor JC211 Inhibitor inhibitor inhibit