store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LEI-401 is a selective and potent NAPE-PLD inhibitor that crosses the blood-brain barrier (IC50: 27 nM).LEI-401 reduces the level of n-acylethanolamines (NAEs) in the brain of free-ranging mice and modulates their emotional behaviour.
説明 | LEI-401 is a selective and potent NAPE-PLD inhibitor that crosses the blood-brain barrier (IC50: 27 nM).LEI-401 reduces the level of n-acylethanolamines (NAEs) in the brain of free-ranging mice and modulates their emotional behaviour. |
ターゲット&IC50 | NAPE-PLD:0.86 μM |
In vitro | In HEK293T cells transfected with hNAPE-PLD, LEI-401 (0.04 - 20 μM; 30 minutes) dose-dependently reduces the labeling of NAPE-PLD, with an IC50 of 0.86 μM. LEI-401 decreases the levels of NAE in Neuro-2a cells but does not reduce them in NAPE-PLD KO cells[1]. |
In vivo | The in vivo pharmacokinetic profile of LEI-401 was evaluated in the plasma of C57BL/6J mice following intraperitoneal (i.p., 30 mg/kg), oral (p.o., 10 mg/kg), or intravenous (i.v., 1 mg/kg) administration. The results demonstrate that LEI-401 is an active NAPE-PLD inhibitor in vivo, indicating its suitability for studying the physiological role of NAPE-PLD[1]. |
別名 | LEI 401 |
分子量 | 421.54 |
分子式 | C24H31N5O2 |
CAS No. | 2393840-15-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (189.78 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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LEI-401 2393840-15-6 Metabolism Phospholipase LEI401 LEI 401 Inhibitor inhibitor inhibit