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Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. leronlimumab has both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronlimab can be used to study HIV non-alcoholic steatohepatitis (NASH) and breast cancer.
説明 | Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. leronlimumab has both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronlimab can be used to study HIV non-alcoholic steatohepatitis (NASH) and breast cancer. |
In vitro |
Leronlimab (1-140 mg/mL) binds to CCR5-positive cells up to 98%[1]. Leronlimab (80-1750 μg/mL) inhibits calcium response induced by CCL5, CCL3, and CCL4 in MDA-MB-231 cells[1]. Leronlimab (175 and 350 mg/mL) blocks the invasion of MDA-MB-231 cells[1]. Leronlimab (10 μg/mL; 72 hours) enhances the cytotoxicity of doxorubicin against MDA-MB-231 cells[1]. |
In vivo | Leronlimab (2 mg; intraperitoneal injection; twice a week) reduces lung metastasis in a mouse xenograft model[1]. |
別名 | PRO 140 |
分子量 | N/A |
CAS No. | 674782-26-4 |
store at low temperature
store at -20°C
You can also refer to dose conversion for different animals. 詳細
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Leronlimab 674782-26-4 Immunology/Inflammation Microbiology/Virology CCR PRO 140 PRO140 PRO-140 Inhibitor inhibitor inhibit