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カタログ番号 | 製品名 | 別名 | ターゲット |
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T25214 | CCR-11 | CCR11,CCR 11 | Antibiotic |
CCR-11 is a tannin-containing derivative with antimicrobial activity. CCR-11 inhibits the proliferation of B. subtilis and HeLa cells. CCR-11 inhibits bacterial proliferation and bacterial cytoplasmic division by inhibit... | |||
T14688 | BMS CCR2 22 | CCR | |
BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM. | |||
T10708 | CCR1 antagonist 6 | CCR | |
CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM). | |||
T10715 | CCR6 inhibitor 1 | CCR | |
CCR6 inhibitor 1 is an effective and selective inhibitor of CCR6 (IC50 of monkey and human CCR6 was 0.45 nM and 6 nM, respectively). CCR6 is associated with both autoimmune and non-autoimmune diseases, so CCR6 inhibitor ... | |||
T11481 | GSK2239633A | CCR | |
T10156 | CCR3 antagonist 1 | CCR | |
CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases. | |||
T13114 | CCR2 antagonist 4 | Teijin compound 1 | CCR |
T4300 | AZD2098 | CCR | |
AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research. | |||
TQ0103 | INCB3344 | CCR | |
TQ0283 | RS102895 | CCR | |
RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1. | |||
T5384 | RS 504393 | CCR | |
RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1). | |||
T14900 | CCR2-RA-[R] | CCR | |
CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM). | |||
T10712 | CCR2 antagonist 3 | AZD-2927,AZD2927 | CCR |
CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2. | |||
T4674 | SB297006 | SB 297006 | CCR |
SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of ... | |||
T24700 | R243 | R 243,R-243 | CCR |
R243 is CCR8 signaling and chemotaxis inhibitor. | |||
T10425 | AZ084 | CCR | |
AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma. | |||
T16111 | ML604086 | CCR | |
ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 binding to CCR8 on circulating T-cells. | |||
T16091 | MK-0812 Succinate | Others , CCR | |
MK-0812 Succinate is an effective and selective CCR2 antagonist. It also has a high affinity at CCR2. | |||
T11699 | J-113863 | CCR | |
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptor... | |||
T3430 | PF-4136309 | INCB8761,PF 4136309 | CCR |
PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist. | |||
T4584 | BMS-813160 | BMS 813160 | CCR |
BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular. | |||
T12773 | RS102895 hydrochloride | Others , 5-HT Receptor , CCR | |
RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM). | |||
T30258 | AZD-4818 | CCR1 antagonist | CCR |
AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease. | |||
T2375 | BX471 | BX 471,BX-471,ZK-811752 | CCR |
BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist. | |||
T7499 | TAK-779 | Takeda 779 | HIV Protease , CXCR , CCR |
TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3). | |||
T10639 | C-021 dihydrochloride | CCR | |
C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM. | |||
T27682 | CCR2 antagonist 5 | JNJ-41443532,JNJ-41443532 Free Base,JNJ 41443532,JNJ41443532 | CCR |
CCR2 antagonist 5 (JNJ-41443532) is a selective and orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM).JNJ-41443532 binds mCCR2 with a Ki of 9.6... | |||
T7624 | DAPTA | DAPTA(TFA),D-Ala-peptide T-amide,Adaptavir | HIV Protease , CCR |
DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities. | |||
T6016 | Maraviroc | Celsentri,UK-427857,Selzentry | HIV Protease , CCR |
Maraviroc (Selzentry) is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-1 entry via CCR5 coreceptor interaction. | |||
TQ0297 | Cenicriviroc | TAK-652,TBR-652 | HIV Protease , CCR |
Cenicriviroc (TAK-652) is an orally active, dual antagonist of CCR2/CCR5. It also inhibits both HIV-1 and HIV-2, and displays potent anti-infective and anti-inflammatory activity. | |||
T17225 | Vercirnon | CCX282-B,GSK-1605786,Traficet-EN | CCR |
Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases. | |||
T10714 | CCR5 antagonist 1 | HIV Protease , CCR | |
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication. | |||
T10713 | CCR4 antagonist 2 | Calcium Channel | |
CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the n... | |||
T10710 | CCR1 antagonist 9 | CCR | |
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay). | |||
T21870 | C-021 | 4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy- | CCR |
C 021 dihydrochloride is a potent CCR4 antagonist. C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) dihydrochloride potently inhibits functional chemotaxis in humans and mice with IC50s ... | |||
T14899 | CCR1 antagonist 8 | CCR | |
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay). | |||
T10709 | CCR1 antagonist 7 | CCR | |
CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1]. | |||
T10711 | CCR2 antagonist 1 | CCR | |
CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM). | |||
T39661 | CCR4 antagonist 3 | CCR4 antagonist 3 | |
CCR4 antagonist 3 is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antago... | |||
T2386 | Pirfenidone | S-7701,AMR-69,S-7701,AMR69 | CCR , TGF-beta/Smad |
Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tum... | |||
T39662 | CCR4 antagonist 3 hydrochloride | ||
CCR4 antagonist 3 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assa... | |||
T3435 | Vicriviroc maleate | SCH-D (maleate),SCH-417690 (maleate) | HIV Protease , CCR |
Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. The IC50 value is 0.91 nM in clinical development for the treatment... | |||
T10716 | CCR7 Ligand 1 | CCR7-Cmp2105 | Others |
T19230 | CCR2 antagonist 4 hydrochloride | Teijin compound 1 hydrochloride | Others |
CCR2 antagonist 4 hydrochloride is a specific CCR2 antagonist (IC50s: 180 nM for CCR2b). It potently inhibits MCP-1-induced chemotaxis (IC50: 24 nM). | |||
T60145 | CCR6 antagonist 1 | CCR | |
CCR6 antagonist 1, a chemical compound acting as a CCR6 antagonist, effectively inhibits the CCL20/CCR6 axis. Its utility lies in research focused on autoimmune-mediated inflammatory diseases, including inflammatory bowe... | |||
T60336 | CCR4 antagonist 3-1 | CCR | |
CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM. CCR4 antagonist 3-1 inhibits the binding of r... | |||
T9983 | CCR8 antagonist 1 | LUN04765 | CCR |
CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM. | |||
T77349 | CCR1/5/8 activator 1 | Phospholipase | |
CCR1/5/8 activator 1 is a cytoplasmic phospholipase A inhibitor with antifungal activity. | |||
T62944 | CCR8 antagonist 2 | ||
CCR8 antagonist 2 is a potent antagonist of CCR8 that inhibits the activity of CCR8 (C-C Motif chemokine receptor 8), which is predominantly expressed on Treg and Th2 cells, and not on Th1 cells. CCR8 antagonist 2 can be... | |||
T64242 | CCR1 antagonist 11 hydrochloride | ||
CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist that acts on hCCR1 (IC50: 0/.03 μM), mCCR1 (IC50: 0.58 μM), rCCR1 (IC50: 0.32 μM). 11 hydrochloride can be used to study rheumatoid arthritis an... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T6413 | Bindarit | AF2838 | CCR |
Bindarit (AF2838) displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. | |||
TN1273 | 7,4'-Dihydroxyflavone | 4',7-Dihydroxyflavone | NF-κB , COX , HDAC , CCR , NOD |
7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-2. | |||
TN2951 | 3-(hydroxymethyl)cyclopentanone | CCR | |
3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the preparation of HIV chemokine CCR-5 receptor antagonists. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPK-00879 | CCR2b Protein-VLP, Human, Recombinant | Human | HEK293 Cells |
The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammator... | |||
TMPK-00896 | CCR8 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ... | |||
TMPK-01316 | CCR8 Protein, Cynomolgus, Recombinant (mFc) | Cynomolgus | HEK293 Cells |
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ... | |||
TMPK-00897 | CCR8 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and ... | |||
TMPH-01064 | CCR4 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger... | |||
TMPH-01065 | CCR4 Protein-VLP, Human, Recombinant (His) | Human | HEK293 Cells |
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger... | |||
TMPH-01066 | CCR6 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
CCR6 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 12.9 kDa and the accession number is P51684. | |||
TMPY-00856 | TCCR Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
TCCR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79 kDa and the accession number is Q6UWB1. | |||
TMPK-00356 | IL-27RA/TCCR Protein, Human, Recombinant (His) | Human | HEK293 Cells |
IL-27Ra (also known as TCCR and WSX1) as a gene whose expression can induce the transformation of hematopoietic cells. IL-27Ra (IL-27R) is a type I cytokine receptor that functions as the ligand binding component of the ... | |||
TMPY-05543 | TCCR Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
TCCR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.6 kDa and the accession number is AAC40121.1. | |||
TMPY-06792 | TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 Cells |
TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 56.37 kDa and the accession number is AAC40121.1. | |||
TMPK-00009 | CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | E. coli |
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited n... | |||
TMPK-00008 | CCL5 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited n... |
カタログ番号 | 製品名 | ||
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L7600 | Chemokine Inhibitor Library | 59 compounds | |
A unique collection of 59 chemokines or chemokine receptors targeted compounds for high throughput and high content screening; |