Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), 1.0 μM (DYRK3), 0.52 μM (DYRK4), and 2.78 μM (GSK3) [1].
説明 | Leucettinib-92 (compound 92) is a kinase inhibitor selective for DYRK/CLK families, displaying IC50 values of 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), 1.0 μM (DYRK3), 0.52 μM (DYRK4), and 2.78 μM (GSK3) [1]. |
In vitro | Leucettinib-92 (0.1-10 μM; 3 min) binds to DYRK1A in SH-SY5Y cells, stabilizing it to withstand melting temperatures above 52°C. Additionally, at a concentration of 1 μM, Leucettinib-92 inhibits the phosphorylation of two DYRK1A substrates, Thr212-Tau and Thr286-cyclin D1 [1]. |
分子量 | 378.49 |
分子式 | C21H22N4OS |
CAS No. | 2732859-57-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Leucettinib-92 2732859-57-1 Cell Cycle/Checkpoint CDK Inhibitor inhibitor inhibit