Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
説明 | TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. |
In vivo | TC11 shows in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation. |
別名 | CLT-003, 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 |
分子量 | 322.4 |
分子式 | C20H22N2O2 |
CAS No. | 100823-03-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (139.57 mM)
You can also refer to dose conversion for different animals. 詳細
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TC11 100823-03-8 Apoptosis Cell Cycle/Checkpoint Proteases/Proteasome BCL CDK Caspase Cyclin dependent kinase Apoptotic Mitotic CLT003 Inhibitor Immunomodulatory TC 11 CLT-003 CLT 003 Derivative inhibit Bcl-2 Family TC-11 Antitumor Phenylphthalimide 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 Death inhibitor