Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lipid 5 is an amino lipid compound that demonstrates proficient mRNA delivery in rodent and primate models, displaying favorable pharmacokinetics and minimal toxicity.
説明 | Lipid 5 is an amino lipid compound that demonstrates proficient mRNA delivery in rodent and primate models, displaying favorable pharmacokinetics and minimal toxicity. |
In vitro | Substituting the linoleic tail for a primary ester-containing lipid tail (Lipid 5) enhances expression and optimizes tissue clearance. Metabolite identification studies on Lipid 5 revealed that the initial metabolic step involves the hydrolysis of the primary ester[1]. |
In vivo | The clearance of Lipid 5 and MC3 from various mouse tissues was evaluated following the administration of 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. The liver and spleen exhibited the highest concentrations of Lipid 5, albeit at significantly lower levels than those of MC3. Detection of Lipid 5 also occurred in the plasma, lung, and kidney, but not in the heart[1]. |
分子量 | 710.182 |
分子式 | C44H87NO5 |
CAS No. | 2089251-33-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Lipid 5 2089251-33-0 Inhibitor inhibitor inhibit