Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.M1002 alters the Tyr2 conformation of the HIF-281alpha PAS-B structural domain and acts synergistically with inhibitors of the prolyl hydroxylase structural domain (PHD).
説明 | M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.M1002 alters the Tyr2 conformation of the HIF-281alpha PAS-B structural domain and acts synergistically with inhibitors of the prolyl hydroxylase structural domain (PHD). |
In vitro | M1002 (10 μM; 24 h; 786-O cells) enhances the expression of HIF-2 target genes with great efficacy compared with the control. M1002 treatment (5 μM) shows synergy with prolyl hydroxylase domain (PHD) inhibitors.[1] |
分子量 | 394.29 |
分子式 | C15H8F6N2O2S |
CAS No. | 823830-85-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (25.36 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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M1002 823830-85-9 Angiogenesis Chromatin/Epigenetic HIF Inhibitor inhibitor inhibit