Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M435-1279 is a UBE2T inhibitor. M435-1279 blocks UBE2T-mediated degradation of RACK1, leading to inhibit the hyperactivation of Wnt/β-catenin signaling pathway.
説明 | M435-1279 is a UBE2T inhibitor. M435-1279 blocks UBE2T-mediated degradation of RACK1, leading to inhibit the hyperactivation of Wnt/β-catenin signaling pathway. |
In vitro | M435-1279 (0, 2, 4, 8, 16, 31 μM; 48 h) significantly inhibits the growth of AGS, HGC27, and MKN45 cells. M435-1279 (0, 4, 8, 12, 16, 20 μM) inhibits the cell viability with IC50s of 16.8, 11.88, 7.76, 6.93 μM of GES-1, HGC27, AGS MKN45, cells, respectively. M435-1279 (31 nM to 500 μM) binds to UBE2T protein with a KD value of 50.5 μM. M435-1279 (11.88 μM; 48 h) blocks the ubiquitination of RACK1, leading to inhibit the hyperactivation of the Wnt/β-catenin pathway[1]. |
In vivo | M435-1279 (5 mg/kg/day; intratumor injection; 18 days) slows the tumor growth. M435-1279 induces higher expression of RACK1 proteins, and lower expression of Ki-67 and β-catenin proteins in intratumor tumors[1]. |
分子量 | 419.47 |
分子式 | C18H17N3O5S2 |
CAS No. | 1359431-16-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (107.3 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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M435-1279 1359431-16-5 Ubiquitination E1/E2/E3 Enzyme M435 1279 M4351279 Inhibitor inhibitor inhibit