store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MFI8 is a compound that regulates mitochondrial fission and can be used to study aging.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 45,500 | |||
10 mg | 在庫あり | ¥ 75,500 | |||
25 mg | 在庫あり | ¥ 149,000 | |||
50 mg | 在庫あり | ¥ 255,000 | |||
100 mg | 在庫あり | ¥ 369,500 | |||
500 mg | 在庫あり | ¥ 739,000 |
説明 | MFI8 is a compound that regulates mitochondrial fission and can be used to study aging. |
ターゲット&IC50 | mitochondrial:4.8 μM (EC50) |
In vitro |
At a concentration of 20 μM for a duration of 6 hours, MFI8 significantly reduces mitochondrial aspect ratio with an EC50 of 4.8 μM. It achieves this by inhibiting mitochondrial function through mitofusins, subsequently promoting mitochondrial fission [1]. MFI8 possesses functional groups that adhere to the pharmacophore model standards. It interacts with mitofusins, facilitating mitochondrial fission [1]. Binding to the HR2 domain of MFN2, MFI8 modulates MFN conformation and complexes, thereby altering mitochondrial function [1].In a concentration-responsive manner (0-20 μM; 6 hours), MFI8 increases caspase-3/7 activity, induces cytochrome c release, and reduces membrane potential in a mitotic protein-dependent manner. Additionally, the combination of MFI8 with BV6 SMAC, a mimic of the second mitochondrial-derived activator of caspases, induces DNA damage and cell death [1]. |
分子量 | 275.77 |
分子式 | C16H18ClNO |
CAS No. | 694488-83-0 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (290.10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MFI8 694488-83-0 Metabolism Mitochondrial Metabolism Inhibitor inhibitor inhibit