Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).
説明 | Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). |
ターゲット&IC50 | Mitochondrial pyruvate carrier:2.5 μM (Ki) |
In vitro | In mice carrying glioma tumors, Lonidamine (160 mg/kg) effectively reduced tumor growth. |
In vivo | In both normal and tumor cells, Lonidamine reduces oxygen consumption while augmenting aerobic glycolysis in normal cells, thereby inhibiting aerobic glycolysis in tumor cells. The compound induces apoptosis at a concentration of 50 mg/ml in resistant cell lines, including the human breast cancer cell line MCF-7 ADR(r) and the LB9 multiform glioblastoma cell line, which exhibit resistance to doxorubicin and nitrosourea. |
別名 | AF1890, DICA, Diclondazolic Acid |
分子量 | 321.16 |
分子式 | C15H10Cl2N2O2 |
CAS No. | 50264-69-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32.1 mg/mL (100 mM)
Ethanol: 1.6 mg/mL (5 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Lonidamine 50264-69-2 Apoptosis Metabolism Hexokinase Mitochondrial Metabolism mitochondrial complex AF1890 AF-1890 lactate lung fibrosis Mitochondrial DICA A549 Inhibitor H2030BrM3 AF 1890 inhibit pulmonary fibrosis Diclondazolic Acid inhibitor