Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Compound 24, also known as Mu opioid receptor antagonist 7, is a potent, centrally-acting µ-opioid receptor (µOR) antagonist with an inhibitory concentration (IC50) of 29 ± 3.0 nM. It is valuable for pain and opioid use disorder research [1].
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 349,000 |
50 mg | 約8-10 週間 | ¥ 454,500 |
100 mg | 約8-10 週間 | ¥ 574,000 |
説明 | Compound 24, also known as Mu opioid receptor antagonist 7, is a potent, centrally-acting µ-opioid receptor (µOR) antagonist with an inhibitory concentration (IC50) of 29 ± 3.0 nM. It is valuable for pain and opioid use disorder research [1]. |
ターゲット&IC50 | μ opioid receptor:29 nM |
In vivo | Mu opioid receptor antagonist 7 (compound 24) at a dose of 10 mg/kg effectively blocks the analgesic effect induced by µOR agonists, demonstrating its ability to antagonize µOR agonists [1]. At the same dose and in rats, it reverses the respiratory depression caused by fentanyl, a potent µOR agonist. Administered subcutaneously in rats, it achieves 70% µOR receptor occupancy, indicating high central nervous system (CNS) penetrability [1]. |
分子量 | 386.91 |
分子式 | C22H27ClN2O2 |
CAS No. | 2378397-30-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Mu opioid receptor antagonist 7 2378397-30-7 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Inhibitor inhibitor inhibit