store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.
説明 | DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction. |
ターゲット&IC50 | μ opioid receptor (Native):3.46±0.84 nM (Kd) |
In vivo | (1) DAMGO inhibits GABAergic inputs in VTA-DA neurons at presynaptic sites; (2) effect of DAMGO on GABAergic inputs in VTA-DA neurons is inhibited by potassium channel blocker 4-aminopyridine (4-AP) and Gi protein inhibitor N-ethyl maleimide (NEM); (3) phospholipase A2 (PLA2) does not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons, but mediates it in the periaqueductal gray (PAG); (4) multiple downstream signaling molecules of l receptors do not mediate the effect of DAMGO on GABAergic inputs in VTA-DA neurons. These results suggest that DAMGO depresses inhibitory synaptic transmission via l receptor-Gi protein-Kv channel pathway in VTA-DA neurons, but via l receptor-PLA2 pathway in PAG |
別名 | Dagol, DAGO, RX-783006 |
分子量 | 513.59 |
分子式 | C26H35N5O6 |
CAS No. | 78123-71-4 |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (64.90 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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DAMGO 78123-71-4 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Dagol RX783006 μ-opioid receptor DAGO RX 783006 RX-783006 inhibit μ-OPR Inhibitor analgesic effect inhibitor