Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases. AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family. An unspecified positional and geometric isomer of 3-oxo-C16:1-(L)-HSL is produced by the F2/5 strain of A. vitis, the bacterium responsible for grape crown gall and its resulting loss of agricultural productivity.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 17,500 |
5 mg | 約 35 days | ¥ 74,500 |
10 mg | 約 35 days | ¥ 129,500 |
25 mg | 約 35 days | ¥ 280,000 |
説明 | Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases. AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family. An unspecified positional and geometric isomer of 3-oxo-C16:1-(L)-HSL is produced by the F2/5 strain of A. vitis, the bacterium responsible for grape crown gall and its resulting loss of agricultural productivity. |
分子量 | 351.487 |
分子式 | C20H33NO4 |
CAS No. | 1269663-80-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 30 mg/mL
DMSO: 30 mg/mL
Ethanol: 30 mg/mL
Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/mL
You can also refer to dose conversion for different animals. 詳細
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N-3-oxo-hexadec-11(Z)-enoyl-L-Homoserine lactone 1269663-80-0 N-3-oxo-hexadec-11enoyl-L-Homoserine lactone N3oxohexadec11(Z)enoylLHomoserine lactone N 3 oxo hexadec 11(Z) enoyl L Homoserine lactone Inhibitor inhibitor inhibit